Rubusoside

Rubusoside is a natural non-caloric sweetener and glycoside form of steviol (Cay-10011344) that has been found in S. rebaudiana leaves and has diverse biological activities. It inhibits glucose transport by glucose transporter 1 (Glut1) and fructose transport by Glut5 (IC50s = 4.6 and 6.7 mM, respectively, for the recombinant human transporters). Rubusoside prevents lipotoxicity induced by palmitic acid (Cay-10006627) in INS-1 mouse insulinoma cells when used at concentrations ranging from 50 to 200 µM. It has been used to enhance the solubility of the anticancer agent etoposide (Cay-12092).Formal Name: (4alpha)-13-(beta-D-glucopyranosyloxy)-kaur-16-en-18-oic acid, beta-D-glucopyranosyl ester. CAS Number: 64849-39-4. Molecular Formula: C32H50O13. Formula Weight: 642.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/mg. SMILES: C[C@]([C@]1([H])CC2)(CCC[C@@]1(C)C(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO)=O)[C@@]4([H])[C@]2(CC5=C)C[C@@]5(O[C@]6([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)CC4. InChi Code: InChI=1S/C32H50O13/c1-15-11-31-9-5-18-29(2,7-4-8-30(18,3)28(41)44-26-24(39)22(37)20(35)16(12-33)42-26)19(31)6-10-32(15,14-31)45-27-25(40)23(38)21(36)17(13-34)43-27/h16-27,33-40H,1,4-14H2,2-3H3/t16-,17-,18+,19+,20-,21-,22+,23+,24-,25-,26+,27+,29-,30-,31-,32+/m1/s1. InChi Key: YWPVROCHNBYFTP-OSHKXICASA-N. Origin: Plant/Malus hupehensis Rehd..