RU-24969 (succinate)

RU-24969 is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B. It binds to 5-HT1A and 5-HT1B receptors (IC50s = 9.5 and 6.6 nM, respectively) and is selective for these receptors over 5-HT2 receptors in cell-free assays (IC50 = 5,120 nM). RU-24969 inhibits tritium efflux induced by the 5-HT antagonist methiothepin (Cay-23138) in tritium-preloaded rat frontal cortex slices (pA2 = 6.27). In vivo, RU-24969 (3 mg/kg) potentiates cocaine-induced increases in nucleus accumbens dopamine levels, as well as the reinforcing effects of cocaine self-administration, in rats.Formal Name: 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole, butanedioic acid (2:1). CAS Number: 66611-27-6. Molecular Formula: C14H16N2O . 1/2C4H6O4. Formula Weight: 287.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: slightly soluble, DMSO: slightly soluble, Ethanol: slightly soluble, PBS (pH 7.2): 1 mg/ml. lambdamax: 223, 264 nm. SMILES: O=C(CCC(O)=O)O.COC1=CC2=C(NC=C2C3=CCNCC3)C=C1.COC4=CC5=C(NC=C5C6=CCNCC6)C=C4. InChi Code: InChI=1S/2C14H16N2O.C4H6O4/c2*1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10,5-3(6)1-2-4(7)8/h2*2-4,8-9,15-16H,5-7H2,1H3,1-2H2,(H,5,6)(H,7,8). InChi Key: BNYJLRQAWCQJOM-UHFFFAOYSA-N.