RTA 408

RTA 408 is a synthetic triterpenoid that binds Keap1 and attenuates the degradation of Nrf2 at concentrations =25 nM. In this way, it suppresses the generation of nitric oxide and pro-inflammatory cytokines in macrophages stimulated with IFN-gamma. At higher concentrations, RTA 408 inhibits tumor cell growth (GI50 = 260 nM), blocks NF-kappaB signaling, and decreases levels of cyclin D1. Topical application of RTA 408 activates Nrf2 and provides cytoprotective effects.Formal Name: N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-propanamide. CAS Number: 1474034-05-3. Synonyms: Omaveloxolone. Molecular Formula: C33H44F2N2O3. Formula Weight: 554.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, Ethanol: 2 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.25 mg/ml. lambdamax: 239 nm. SMILES: O=C1[C@@]2([H])[C@](CC[C@]3(NC(C(F)(F)C)=O)[C@@]2([H])CC(C)(C)CC3)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=C1)=O. InChi Code: InChI=1S/C33H44F2N2O3/c1-27(2)11-13-33(37-26(40)32(8,34)35)14-12-31(7)24(20(33)17-27)21(38)15-23-29(5)16-19(18-36)25(39)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3,(H,37,40)/t20-,22-,24-,29-,30+,31+,33-/m0/s1. InChi Key: RJCWBNBKOKFWNY-IDPLTSGASA-N.