RS 504393

RS 504393 is a selective antagonist of the MCP-1 receptor CCR2 (IC50s = 89 nM and >100 µM for CCR2 and CCR1, respectively). It has been shown to inhibit MCP-1-stimulated chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.Formal Name: 6-methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one. CAS Number: 300816-15-3. Molecular Formula: C25H27N3O3. Formula Weight: 417.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 1 mg/ml, Ethanol: Slightly soluble. lambdamax: 246, 281 nm. SMILES: CC1=CC=C(NC(OC23CCN(CCC4=C(C)OC(C5=CC=CC=C5)=N4)CC3)=O)C2=C1. InChi Code: InChI=1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29). InChi Key: ODNICNWASXKNNQ-UHFFFAOYSA-N.