Rp-8-pCPT-Cyclic GMPS (sodium salt)

Rp-8-pCPT-Cyclic GMPS is a stable, cell-permeable cGMP analog that competitively inhibits cGMP-dependent protein kinases (cGKs), including cGK Ialpha and cGK II (IC50s = 18.3 and 0.16 µM, respectively). The pCPT (p-chlorophenylthio) group at the 8-position of the purine increases both enzyme affinity and membrane permeability over related compounds. At 10 µM, it blocks the relaxation of rat tail arteries induced by the nitric oxide donor SIN-1 (Cay-82220).Formal Name: 8-[(4-chlorophenyl)thio]-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] guanosine, monosodium salt. CAS Number: 208445-07-2. Synonyms: Rp-8-pCPT-cGMPS. Molecular Formula: C16H14ClN5O6PS2 . Na. Formula Weight: 525.9. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: soluble. SMILES: O[C@H]1[C@H](N2C(SC3=CC=C(Cl)C=C3)=NC4=C2N=C(N)NC4=O)O[C@H]5[C@H]1O[P@@](OC5)([S-])=O.[Na+]. InChi Code: InChI=1S/C16H15ClN5O6PS2.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(27-14)5-26-29(25,30)28-11,/h1-4,8,10-11,14,23H,5H2,(H,25,30)(H3,18,20,21,24),/q,+1/p-1/t8-,10-,11-,14-,29-,/m1./s1. InChi Key: JERAACMSJYSCBY-TXBWCVORSA-M.