Rp-8-CPT-cAMPS sodium

Description: Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS .[1] It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II.2 By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.[2],[3]. Target: Others. Smiles: [Na].[H][C@@]12COP(S)(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)n1c(Sc2ccc(Cl)cc2)nc2c(N)ncnc12. References: Schwede, F., Maronde, F., Genieser, H., et al. Cyclic nucleotide analogs as biochemical tools and prospective drugs. Pharmacology & Therapeutics 87(2), 199-226 (2000).