Roxatidine-d10 (hemioxalate)

Roxatidine-d10 is intended for use as an internal standard for the quantification of roxatidine by GC- or LC-MS. Roxatidine is a histamine H2 receptor antagonist and major active metabolite of roxatidine acetate (Cay-21248). Roxatidine reduces histamine-induced adenylate cyclase production in guinea pig parietal cells (IC50 = 0.8 µM). It inhibits histamine-induced hydrogen ion accumulation in the same cells (pA2 = 7.03). Roxatidine (200 mg/kg) reduces small intestinal lesion area in a rat model of gastric mucosal injury induced by indomethacin (Cay-70270).Formal Name: 2-hydroxy-N-[3-[3-(1-piperidinyl-2,2,3,3,4,4,5,5,6,6-d10-methyl)phenoxy]propyl]-acetamide, ethanedioate (2:1). CAS Number: 2832423-41-1. Molecular Formula: C17H16D10N2O3 . 1/2C2H2O4. Formula Weight: 361.5. Purity: >99% deuterated forms (d1-d10). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Water: soluble. SMILES: OCC(NCCCOC1=CC=CC(CN2C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C2([2H])[2H])=C1)=O.OC(C(O)=O)=O. InChi Code: InChI=1S/2C17H26N2O3.C2H2O4/c2*20-14-17(21)18-8-5-11-22-16-7-4-6-15(12-16)13-19-9-2-1-3-10-19,3-1(4)2(5)6/h2*4,6-7,12,20H,1-3,5,8-11,13-14H2,(H,18,21),(H,3,4)(H,5,6)/i2*1D2,2D2,3D2,9D2,10D2,. InChi Key: HCVXGACZDFYYTI-JUUMQSSDSA-N.