Rottlerin

Description: Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCdelta of 3-6 µM, PKCalpha,beta,gamma of 30-42 µM, PKCepsilon,eta,zeta of 80-100 µM). Rottlerin causes apoptosis via caspase 3 activation. Target: Autophagy, Apoptosis, CaMK, HIV Protease, Others, PKC, PKA. Smiles: CC(=O)c1c(O)c(C)c(O)c(Cc2c(O)c3C=CC(C)(C)Oc3c(C(=O)\C=C\c3ccccc3)c2O)c1O. References: Gschwendt M, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994 Feb 28,199(1):93-8.