Rosuvastatin (calcium salt)

Rosuvastatin is an inhibitor of HMG-CoA reductase (IC50 = 5 nM). It inhibits cholesterol synthesis in isolated rat hepatocytes with an IC50 value of 0.16 nM. Rosuvastatin (10 mg/kg) reduces plasma total cholesterol, triglyceride, LDL-C, and oxidized LDL-C levels in Ldlr-/- mice fed a high-fat diet. It decreases the area of aortic atherosclerotic lesions in the same model. Formulations containing rosuvastatin have been used in the treatment of dyslipidemias.Formal Name: (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid, hemicalcium salt. CAS Number: 147098-20-2. Synonyms: ZD 4522. Molecular Formula: C22H27FN3O6S . 1/2Ca. Formula Weight: 500.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 243 nm. SMILES: O[C@@H](C[C@@H](O)CC([O-])=O)/C=C/C(C(C1=CC=C(F)C=C1)=NC(N(C)[S](C)(=O)=O)=N2)=C2C(C)C.O[C@@H](C[C@@H](O)CC([O-])=O)/C=C\C(C(C3=CC=C(F)C=C3)=NC(N(C)[S](C)(=O)=O)=N4)=C4C(C)C.[Ca+2]. InChi Code: InChI=1S/3C22H28FN3O6S.Ca/c3*1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32,/h3*5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30),/q,,,+2/p-3/b3*10-9+,/t3*16-,17-,/m111./s1. InChi Key: VGAZDTHGPVFCCO-YFRSHGDPSA-K.