Roslin-2

Roslin-2 is a reactivator of p53. Roslin-2 (111, 333, and 1000 µM) impairs the interaction between focal adhesion kinase (FAK) and p53 and restores p53 transcriptional activity. It reverses FAK-mediated suppression of the expression of p53-dependent p21, MDM2, and Bax in wild-type p53 HCT116 colon and MCF-7 breast cancer cells, but not in p53 mutant SW620 colon cancer cells, when used at concentrations ranging from 1 to 50 µM. Roslin-2 (10 µM) potentiates the pro-apoptotic effect of doxorubicin (Cay-15007) and 5-fluorouracil (Cay-14416) in p53+/+, but not p53-/-, HCT116 cells. It reduces tumor growth and activates p21 in p53+/+, but not p53-/- tumors, in HCT116 mouse xenograft models when administered at a dose of 60 mg/kg.Formal Name: 1-(phenylmethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane, monobromide. CAS Number: 29574-21-8. Molecular Formula: C13H19N4 . Br. Formula Weight: 311.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble. SMILES: [N@@]12C[N+](C[N@](C2)C3)(CC4=CC=CC=C4)C[N@]3C1.[Br-]. InChi Code: InChI=1S/C13H19N4.BrH/c1-2-4-13(5-3-1)6-17-10-14-7-15(11-17)9-16(8-14)12-17,/h1-5H,6-12H2,1H/q+1,/p-1. InChi Key: YJMKPGPWDHCYCD-UHFFFAOYSA-M.