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Product information "(-)-Ropivacaine (hydrochloride hydrate)"
(-)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (-)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 µL of an 8 mM solution is injected percutaneously into the sciatic nerve. (-)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (-)- and (±)-bupivacaine (Cay-16618). Formulations containing (-)-ropivacaine have been used as local anesthetics during surgery and childbirth.Formal Name: (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide, monohydrochloride, monohydrate. CAS Number: 132112-35-7. Synonyms: LEA 103, (S)-Ropivacaine. Molecular Formula: C17H26N2O . HCl [H2O]. Formula Weight: 328.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 25 mg/ml, Ethanol: 15 mg/ml, PBS (pH 7.2): 0.25 mg/ml. SMILES: CC1=CC=CC(C)=C1NC([C@H]2N(CCC)CCCC2)=O.Cl.O. InChi Code: InChI=1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3,,/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20),1H,1H2/t15-,,/m0../s1. InChi Key: VSHFRHVKMYGBJL-CKUXDGONSA-N.
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