Ropidoxuridine

Ropidoxuridine is a radiosensitizer and a prodrug form of the antiviral compound idoxuridine (Cay-20222). It also inhibits viral plaque formation in HeLa cells infected by herpes simplex virus 1 (HSV-1) or HSV-2 when used at a concentration of 100 µM. Ropidoxuridine (1,000 mg/kg per day for six days) enhances radiation-induced decreases in tumor growth without reducing body weight in an HT-29 colon cancer mouse xenograft model. It increases animal survival in a mouse model of lethal HSV-2 infection when administered at a dose of 100 mg/kg every five days.Formal Name: 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-iodo-2(1H)-pyrimidinone. CAS Number: 93265-81-7. Synonyms: IPdR, 5-Iodo-2-pyrimidinone-2'-deoxyribose. Molecular Formula: C9H11IN2O4. Formula Weight: 338.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O[C@@H]1[C@@H](CO)O[C@@H](N2C=C(I)C=NC2=O)C1. InChi Code: InChI=1S/C9H11IN2O4/c10-5-2-11-9(15)12(3-5)8-1-6(14)7(4-13)16-8/h2-3,6-8,13-14H,1,4H2/t6-,7+,8+/m0/s1. InChi Key: XIJXHOVKJAXCGJ-XLPZGREQSA-N.