RO8994

Item number	Size	Delivery time	Price
TGM-T3517-1mg	1 mg	7 - 10 business days*	34.00€
TGM-T3517-2mg	2 mg	7 - 10 business days*	48.00€
TGM-T3517-5mg	5 mg	7 - 10 business days*	78.00€
TGM-T3517-1mL	1 ml	7 - 10 business days*	105.00€
TGM-T3517-10mg	10 mg	7 - 10 business days*	126.00€
TGM-T3517-25mg	25 mg	7 - 10 business days*	237.00€
TGM-T3517-50mg	50 mg	7 - 10 business days*	375.00€
TGM-T3517-100mg	100 mg	7 - 10 business days*	557.00€

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Description: RO8994 is a highly effective and specific inhibitor of spiroindolinone... more

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Product information "RO8994"

Description: RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays). Target: p53, E1/E2/E3 Enzyme, Mdm2. Smiles: COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21)C(N)=O. References: Zhang Z,et al. Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg Med Chem. 2014 Aug 1,22(15):4001-9.

Supplier:	TargetMol
Supplier-Nr:	T3517

Properties

Application:	MDM2-p53 protein-protein interaction inhibitor
MW:	613.51 D
Formula:	C31H31Cl2FN4O4

Database Information

CAS :	1309684-94-3\| Matching products
KEGG ID :	K04451 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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