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![RO5166017](https://www.biomol.com/media/image/78/bf/90/Cay32972-5_600x600.png)
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RO5166017 is an agonist of trace amine-associated receptor 1 (TAAR1). It binds to TAAR1 (Kis =... more
Product information "RO5166017"
RO5166017 is an agonist of trace amine-associated receptor 1 (TAAR1). It binds to TAAR1 (Kis = 31, 24, 1.9, and 2.7 nM in HEK293 cells expressing the recombinant human, cynomolgus monkey, mouse, or rat receptor, respectively) and is greater than 15-fold selective for TAAR1 over a panel of 123 receptors, ion channels, and transporters at 10 µM. RO5166017 induces cAMP production in HEK293 cells expressing the recombinant human, cynomolgus monkey, mouse, or rat TAAR1 (EC50s = 55, 97, 3.3, and 14 nM, respectively). It reduces the frequency of neuronal firing in mouse ventral tegmental area (VTA) and dorsal raphe nucleus (DRN) slices (IC50s = 1.73 and 2.99 nM, respectively), which endogenously express high levels of dopaminergic and serotonergic neurons, respectively. RO5166017 (0.3 mg/kg) inhibits stress-induced hyperthermia, indicating anxiolytic-like activity, as well as reduces cocaine-induced hyperlocomotion, in mice. It also impairs expression, but not reconsolidation, of cocaine-induced place preference in rats.Formal Name: (4S)-2-amino-N-ethyl-4,5-dihydro-N-phenyl-4-oxazolemethanamine. CAS Number: 1048346-74-2. Molecular Formula: C12H17N3O. Formula Weight: 219.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 253 nm. SMILES: CCN(C1=CC=CC=C1)C[C@H]2COC(N)=N2. InChi Code: InChI=1S/C12H17N3O/c1-2-15(11-6-4-3-5-7-11)8-10-9-16-12(13)14-10/h3-7,10H,2,8-9H2,1H3,(H2,13,14)/t10-/m0/s1. InChi Key: PPONHQQJLWPUPH-JTQLQIEISA-N.
Keywords: | (4S)-2-amino-N-ethyl-4,5-dihydro-N-phenyl-4-oxazolemethanamine |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32972 |
Properties
Application: | TAAR1 agonist |
MW: | 219.3 D |
Formula: | C12H17N3O |
Purity: | >95% |
Format: | Crystalline Solid |
Database Information
CAS : | 1048346-74-2| Matching products |
KEGG ID : | K05051 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H302 |
P Phrases: | P264, P270, P330, P301+P310, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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