RO-3

RO-3 is a dual antagonist of the purinergic receptor subtypes P2X3 and P2X2/3 (IC50s = 0.1 and 1.26 µM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 receptors (IC50s = >10 µM for all) but is an antagonist of ML1-type melatonin receptors (IC50 = 0.398 µM).Formal Name: 5-[[4,5-dimethoxy-2-(1-methylethyl)phenyl]methyl]-2,4-pyrimidinediamine. CAS Number: 1026582-88-6. Molecular Formula: C16H22N4O2. Formula Weight: 302.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 12 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 0.2 mg/ml. SMILES: CC(C)C1=CC(OC)=C(OC)C=C1CC2=CN=C(N)N=C2N. InChi Code: InChI=1S/C16H22N4O2/c1-9(2)12-7-14(22-4)13(21-3)6-10(12)5-11-8-19-16(18)20-15(11)17/h6-9H,5H2,1-4H3,(H4,17,18,19,20). InChi Key: PYNPWUIBJMVRIG-UHFFFAOYSA-N.