Ritlecitinib tosylate

Description: Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor. PF-06651600 is a potent and low clearance compound with demonstrated in vivo efficacy. The favorable efficacy and safety profile of this JAK3-specific inhibitor PF-06651600 led to its evaluation in several human clinical studies. JAK3 was among the first of the JAKs targeted for therapeutic intervention due to the strong validation provided by human SCID patients displaying JAK3 deficiencies. Target: Others. Smiles: Cc1ccc(cc1)S(O)(=O)=O.C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12