Ribavirin

Ribavirin is an antiviral guanosine nucleoside analog. Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 µg/ml). Ribavirin also reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 109.5 µM). Aerosol administration of ribavirin (30 mg/kg) reduces mortality in a mouse model of influenza A infection. Formulations containing ribavirin have been used in the treatment of respiratory syncytial virus (RSV), hepatitis C virus (HCV), and viral hemorrhagic fevers.Formal Name: 1-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide. CAS Number: 36791-04-5. Synonyms: NSC 163039. Molecular Formula: C8H12N4O5. Formula Weight: 244.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 11 mg/ml. SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2N=C(C(N)=O)N=C2)O1. InChi Code: InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1. InChi Key: IWUCXVSUMQZMFG-AFCXAGJDSA-N.