RHC-80267

RHC-80267 is an inhibitor of diacylglycerol lipase (DAGL, IC50 = 4 µM for the canine platelet enzyme). It also inhibits the serine hydrolases KIAA1363, fatty acid amide hydrolase (FAAH), BAT5, phospholipase A2 (PLA2), hormone-sensitive lipase (HSL), and acetylcholinesterase (AChE) by greater than 60% when used at a concentration of 50 µM. RHC-80267 (0.1-10 µM) potentiates ACh-induced relaxation of isolated rat mesenteric arteries.Formal Name: 1,1'-[O,O'-[1,6-hexanediylbis(iminocarbonyl)]dioxime]. CAS Number: 83654-05-1. Synonyms: U-57908. Formula Weight: 394.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 5 mg/ml, Ethanol: 5 mg/ml. SMILES: O=C(NCCCCCCNC(O/N=C1CCCCC/1)=O)O/N=C2CCCCC\2. InChi Code: InChI=1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26). InChi Key: RXSVYGIGWRDVQC-UHFFFAOYSA-N.