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RGFP109 is a brain-penetrant inhibitor of histone deacetylases (HDACs, IC50s = 60 and 50 nM, Kis = 32 and 5 nM for HDAC1 and HDAC3 in cell-free assays, respectively). It has been shown to upregulate frataxin mRNA levels in cultured cells obtained from Friedreich's ataxia patients and in a GAA repeat-based mouse model of Friedreich's ataxia.Formal Name: N-[6-[(2-aminophenyl)amino]-6-oxohexyl]-4-methyl-benzamide. CAS Number: 1215493-56-3. Synonyms: RG-2833. Molecular Formula: C20H25N3O2. Formula Weight: 339.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:6): 0.14mg/ml, DMSO: 20 mg/ml, Ethanol: 1.67 mg/ml. lambdamax: 290 nm. SMILES: NC1=C(NC(CCCCCNC(C2=CC=C(C)C=C2)=O)=O)C=CC=C1. InChi Code: InChI=1S/C20H25N3O2/c1-15-10-12-16(13-11-15)20(25)22-14-6-2-3-9-19(24)23-18-8-5-4-7-17(18)21/h4-5,7-8,10-13H,2-3,6,9,14,21H2,1H3,(H,22,25)(H,23,24). InChi Key: VOPDXHFYDJAYNS-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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