Reparixin (L-Lysine salt)

Reparixin is a non-competitive allosteric inhibitor of the activation of CXCR1 and CXCR2 chemokine receptors by IL-8 (IC50s = 1 and 100 nM, respectively). It blocks a range of activities related to IL-8 signaling, including leukocyte recruitment (IC50 = 1 nM) and other inflammatory responses, without affecting receptor activation induced by other CXCR1 and CXCR2 agonists. In spontaneously hypertensive rats, 5 mg/kg reparixin administered daily for three weeks reduces blood pressure by inhibiting hypertension-related mediators, IL-8, 12-lipoxygenase, and endothelin-1. Reparixin blockade (100 nM) of CXCR1 depletes a cancer stem cell population in human breast cancer cell lines in vitro.Formal Name: (alphaR)-alpha-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)benzeneacetamide, L-lysine. CAS Number: 266359-93-7. Synonyms: Repertaxin. Molecular Formula: C14H21NO3S . C6H14N2O2. Formula Weight: 429.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: slightly soluble, DMSO: 10 mg/ml, Ethanol: slightly soluble, PBS (pH 7.2): 10 mg/ml. lambdamax: 202 nm. SMILES: CS(NC([C@H](C)C1=CC=C(CC(C)C)C=C1)=O)(=O)=O.OC([C@@H](N)CCCCN)=O. InChi Code: InChI=1S/C14H21NO3S.C6H14N2O2/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18,7-4-2-1-3-5(8)6(9)10/h5-8,10-11H,9H2,1-4H3,(H,15,16),5H,1-4,7-8H2,(H,9,10)/t11-,5-/m10/s1. InChi Key: JEJFWWFZAQBZMJ-GVKMLHTLSA-N.