Repaglinide-d5

Repaglinide-d5 is intended for use as an internal standard for the quantification of repaglinide (Cay-19387) by GC- or LC-MS. Repaglinide is a metaglitinide antidiabetic agent that blocks ATP-dependent potassium (Kir6) channels in pancreatic beta-cells (Kd = 0.42 nM for the sulphonylurea receptor SUR1 when co-expressed with Kir6.2). In vivo, repaglinide lowers blood glucose in fasted rats and dogs (ED50s = 10 and 28.3 µg/kg, respectively). Formulations containing repaglinide have been used to control blood sugar levels in patients with type 2 diabetes.Formal Name: 2-(ethoxy-1,1,2,2,2-d5)-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]-benzoic acid. CAS Number: 1217709-85-7. Molecular Formula: C27H31D5N2O4. Formula Weight: 457.6. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 25 mg/ml. SMILES: CC(C[C@@H](C1=CC=CC=C1N2CCCCC2)NC(CC3=CC(OC([2H])([2H])C([2H])([2H])[2H])=C(C=C3)C(O)=O)=O)C. InChi Code: InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1/i1D3,4D2. InChi Key: FAEKWTJYAYMJKF-NTSVIFQKSA-N.