Rec 15/2615 (hydrochloride)

Description: Rec 15/2615 is an antagonist of alpha1B-adrenergic receptors (alpha1B-ARs, Ki = 0.45 nM for the recombinant human receptor).1 It selectively inhibits alpha1B-ARs over alpha1A-, alpha1D-, and alpha1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively). Rec 15/2615 inhibits norepinephrine-induced contractions of isolated rabbit prostate and urethral strips (Kis = 100 and 316.2 nM, respectively), as well as reduces norepinephrine-induced contractions of chloroethylclonidine-precontracted isolated rabbit aortic rings (Ki = 50 nM).2 It decreases diastolic blood pressure (ED25 = 183 µg/kg, i.v.) and increases intracavernous pressure in anesthetized dogs when administered intracavernously at doses ranging from 30 and 1,000 µg/kg.1,2. Target: Others. Smiles: O=C(COC1=C(C(C)C)C=CC=C1OC)N2CCN(CC2)C3=NC4=C(C=C(C(OC)=C4)OC)C(N)=N3.Cl.Cl. References: Sironi, G., Colombo, D., Poggesi, E., et al. Effects of intracavernous administration of selective antagonists of alpha1-adrenoceptor subtypes on erection in anesthetized rats and dogs. J. Pharmacol. Exp. Ther. 292(3), 974-981 (2000).