Rec 15/2615 (hydrochloride)

Rec 15/2615 is an antagonist of alpha1B-adrenergic receptors (alpha1B-ARs, Ki = 0.45 nM for the recombinant human receptor). It selectively inhibits alpha1B-ARs over alpha1A-, alpha1D-, and alpha1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively). Rec 15/2615 inhibits norepinephrine-induced contractions of isolated rabbit prostate and urethral strips (Kis = 100 and 316.2 nM, respectively), as well as reduces norepinephrine-induced contractions of chloroethylclonidine-precontracted isolated rabbit aortic rings (Ki = 50 nM). It decreases diastolic blood pressure (ED25 = 183 µg/kg, i.v.) and increases intracavernous pressure in anesthetized dogs when administered intracavernously at doses ranging from 30 and 1,000 µg/kg.Formal Name: 1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-[2-methoxy-6-(1-methylethyl)phenoxy]-ethanone, dihydrochloride. CAS Number: 1782573-48-1. Synonyms: SB 216469. Molecular Formula: C26H33N5O5 . 2HCl. Formula Weight: 568.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM. SMILES: COC1=CC2=C(C(N)=NC(N3CCN(C(COC4=C(C(C)C)C=CC=C4OC)=O)CC3)=N2)C=C1OC.Cl.Cl. InChi Code: InChI=1S/C26H33N5O5.2ClH/c1-16(2)17-7-6-8-20(33-3)24(17)36-15-23(32)30-9-11-31(12-10-30)26-28-19-14-22(35-5)21(34-4)13-18(19)25(27)29-26,,/h6-8,13-14,16H,9-12,15H2,1-5H3,(H2,27,28,29),2*1H. InChi Key: XZGSTPYGKYGQLD-UHFFFAOYSA-N.