RBN-2397

RBN-2397 is an inhibitor of poly(ADP-ribose) polymerase 7 (PARP7). It stabilizes wild-type PARP7 levels, but not levels of the catalytically inactive mutant PARP7H532A, in COS-1 cells expressing wild-type or mutant PARP7, respectively, when used at a concentration of 100 nM. RBN-2397 (100 nM) also decreases wild-type PARP7 catalytic activity in the same cells.Formal Name: 5-[[(1S)-1-methyl-2-[3-oxo-3-[4-[5-(trifluoromethyl)-2-pyrimidinyl]-1-piperazinyl]propoxy]ethyl]amino]-4-(trifluoromethyl)-3(2H)-pyridazinone. CAS Number: 2381037-82-5. Molecular Formula: C20H23F6N7O3. Formula Weight: 523.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml. lambdamax: 221, 254 nm. SMILES: FC(F)(C1=C(C=NNC1=O)N[C@@H](C)COCCC(N2CCN(C3=NC=C(C(F)(F)F)C=N3)CC2)=O)F. InChi Code: InChI=1S/C20H23F6N7O3/c1-12(30-14-10-29-31-17(35)16(14)20(24,25)26)11-36-7-2-15(34)32-3-5-33(6-4-32)18-27-8-13(9-28-18)19(21,22)23/h8-10,12H,2-7,11H2,1H3,(H2,30,31,35)/t12-/m0/s1. InChi Key: UQZCQKXJAXKZQH-LBPRGKRZSA-N.