RBI 257 (maleate)

RBI 257 is a potent dopamine D4 receptor antagonist (Ki = 0.3 nM) that is selective over D2L, D3, D2-like, and D1 receptors by 1,721-, 439-, 1,336-, and 8,576-fold, respectively.Formal Name: N-[1-[(4-iodophenyl)methyl]-4-piperidinyl]-N-methyl-3-(1-methylethoxy)-2-pyridinamine (2Z)-2-butenedioate. CAS Number: 911378-38-6. Molecular Formula: C21H28IN3O . C4H4O4. Formula Weight: 581.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 240, 295 nm. SMILES: IC1=CC=C(CN2CCC(N(C)C3=NC=CC=C3OC(C)C)CC2)C=C1.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C21H28IN3O.C4H4O4/c1-16(2)26-20-5-4-12-23-21(20)24(3)19-10-13-25(14-11-19)15-17-6-8-18(22)9-7-17,5-3(6)1-2-4(7)8/h4-9,12,16,19H,10-11,13-15H2,1-3H3,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: NIRRRTUKUHIOTQ-BTJKTKAUSA-N.