Rauwolscine hydrochloride

Description: Rauwolscine hydrochloride (Isoyohimbine hydrochloride) , a natural alkaloid, is a specific and reversible alpha2-adrenergic receptor antagonist (Ki: 12 nM) [1]. It is a stereoisomer of yohimbine, which potently antagonizes both alpha1- and alpha2-adrenergic receptors [1]. Rauwolscine hydrochloride also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki: 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50: 1.3 µM) [3]. The alpha2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior [5]. Target: Adrenergic Receptor. Smiles: Cl.[H][C@]12CC[C@H](O)[C@@H](C(=O)OC)[C@@]1([H])C[C@]1([H])N(CCc3c1[nH]c1ccccc31)C2. References: Perry B D, U'Prichard D C. [3H] Rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha2-adrenergic receptors[J]. European journal of pharmacology, 1981, 76(4): 461-464.