Ranitidine-d6 (hydrochloride)

Ranitidine-d6 is intended for use as an internal standard for the quantification of ranitidine (Cay-16939) by GC- or LC-MS. Ranitidine is a histamine H2 receptor antagonist. It reverses histamine-induced relaxation of isolated rat uterine horn (pA2 = 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA2 = 7.2). Ranitidine (0.03-3 mg/kg, i.v.) inhibits histamine-and pentagastrin-induced gastric acid secretion in a dose-dependent manner in anesthetized rats. Formulations containing ranitidine have been used in the treatment and prevention of heartburn and gastroesophageal reflux disease (GERD).Formal Name: (E)-N-(2-(((5-((bis(methyl-d3)amino)methyl)furan-2-yl)methyl)thio)ethyl)-N'-methyl-2-nitroethene-1,1-diamine, monohydrochloride. CAS Number: 1185238-09-8. Molecular Formula: C13H16D6N4O3S . HCl. Formula Weight: 356.9. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 231, 326 nm. SMILES: CN/C(NCCSCC1=CC=C(CN(C([2H])([2H])[2H])C([2H])([2H])[2H])O1)=C\[N+]([O-])=O.Cl. InChi Code: InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3,/h4-5,9,14-15H,6-8,10H2,1-3H3,1H/b13-9+,/i2D3,3D3,. InChi Key: GGWBHVILAJZWKJ-DICWLCDHSA-N.