Racecadotril-d5

Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril (Cay-20390) by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan (Cay-15600). In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-induced diarrhea. Formulations containing racecadotril have been used in the treatment of acute diarrhea.Formal Name: N-[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]-glycine, (phenyl-d5)methyl ester. CAS Number: 1246815-11-1. Synonyms: Acetorphan-d5. Molecular Formula: C21H18D5NO4S. Formula Weight: 390.5. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: [2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1COC(CNC(C(CSC(C)=O)CC2=CC=CC=C2)=O)=O. InChi Code: InChI=1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)/i3D,6D,7D,10D,11D. InChi Key: ODUOJXZPIYUATO-LKOJFEAXSA-N.