rac-trans-4-hydroxy Glyburide

Description: rac-trans-4-hydroxy Glyburide, an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide, is formed by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. It inhibits glyburide binding to rat brain synaptosomes at high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively. Target: Others. Smiles: COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)N[C@H]1CC[C@H](O)CC1 , wU:27.28,wD:30.32,(-4,-25.41,,-4,-23.87,,-5.33,-23.1,,-6.67,-23.87,,-8,-23.1,,-8,-21.56,,-9.34,-20.79,,-6.67,-20.79,,-5.33,-21.56,,-4,-20.79,,-2.67,-21.56,,-4,-19.25,,-2.67,-18.48,,-2.67,-16.94,,-1.33,-16.17,,-1.33,-14.63,,,-13.86,,1.33,-14.63,,1.33,-16.17,,,-16.94,,2.67,-13.86,,1.9,-12.53,,3.44,-15.19,,4,-13.09,,5.33,-13.86,,5.33,-15.4,,6.67,-13.09,,8,-13.86,,9.34,-13.09,,10.67,-13.86,,10.67,-15.4,,12,-16.17,,9.34,-16.17,,8,-15.4,), . References: Zharikova, O.L., Fokina, V.M., Nanovskaya, T.N., et al.Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburideBiochem. Pharmacol.78(12)1483-1490(2009)