RA-2

RA-2 is an inhibitor of small-conductance calcium-activated potassium channel 2.3 (KCa2.3/SK3) and intermediate-conductance calcium-activated potassium channel 3.1 (KCa3.1/IK1) (IC50s = 2 and 17 nM, respectively). It is selective for these channels over KCa1.1/BK1, voltage-gated potassium channel 1.2 (Kv1.2), Kv1.3, Kv7.4, human-ether-a-go-go (hERG), also known as Kv11.1, and the inward-rectifier potassium channel (Kir), but also inhibits KCa2.1 and KCa2.2 by 96 and 90%, respectively, at 1 µM. RA-2 (1 µM) inhibits bradykinin-induced relaxation of porcine coronary artery rings precontracted with the TP receptor agonist U-46619 (Cay-16450). It decreases heart rate, but not mean arterial blood pressure, in mice when administered at a dose of 30 mg/kg.Formal Name: 3-fluoro-4-hydroxy-1,1'-[1,3-phenylenebis(methylene)] ester, benzoic acid. CAS Number: 1867107-62-7. Molecular Formula: C22H16F2O6. Formula Weight: 414.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 5 mg/ml, Ethanol: 15 mg/ml. SMILES: O=C(C1=CC=C(C(F)=C1)O)OCC2=CC=CC(COC(C3=CC=C(C(F)=C3)O)=O)=C2. InChi Code: InChI=1S/C22H16F2O6/c23-17-9-15(4-6-19(17)25)21(27)29-11-13-2-1-3-14(8-13)12-30-22(28)16-5-7-20(26)18(24)10-16/h1-10,25-26H,11-12H2. InChi Key: XOZKRECPKXTNAK-UHFFFAOYSA-N.