R112

R112 is an inhibitor of spleen tyrosine kinase (Syk, IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM). It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC50 value of 490 nM. R112 inhibits the production of leukotriene C4 (LTC4, Cay-20210) and decreases cytokine levels in cultured human mast cells.Formal Name: 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-phenol. CAS Number: 575474-82-7. Molecular Formula: C16H13FN4O2. Formula Weight: 312.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 30 mg/ml. lambdamax: 271, 321 nm. SMILES: OC1=CC=CC(NC2=NC=C(F)C(NC3=CC(O)=CC=C3)=N2)=C1. InChi Code: InChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21). InChi Key: TVKGTSHBQZEFEE-UHFFFAOYSA-N.