(R)-Baclofen hydrochloride

Description: Arbaclofen hydrochloride, a Gamma-Aminobutyric Acid derivative, is a specific agonist of GABA-B receptors, it is used to treat spasticity, especially that due to spinal cord damage. It acts at spinal and supraspinal sites, generally reduces excitatory transmission. Target: GABA Receptor. Smiles: [C@H](CC(O)=O)(CN)C1=CC=C(Cl)C=C1.Cl. References: Berry-Kravis E, Hagerman R, Visootsak J, Budimirovic D, Kaufmann WE, Cherubini M, Zarevics P, Walton-Bowen K, Wang P, Bear MF, Carpenter RL. Arbaclofen in fragile X syndrome: results of phase 3 trials. J Neurodev Disord. 2017 Jun 12,9:3. doi: 10.1186/s11689-016-9181-6. eCollection 2017. PubMed PMID: 28616094, PubMed Central PMCID: PMC5467054.