Quillaic Acid

Quillaic acid is a triterpene saponin that has been found in Q. saponaria bark and has diverse biological activities. It is cytotoxic to SNU-1 and KATO III gastric cancer cells (IC50s = 13.6 and 67 µM, respectively). Quillaic acid induces hot plate analgesia in mice (ED50 = 20.7 mg/kg). It reduces ear edema induced by arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) or phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in mice when administered topically at doses of 0.7 and 1.6 mg/ear, respectively.Formal Name: (3beta,4alpha,16alpha)-3,16-dihydroxy-23-oxo-olean-12-en-28-oic acid. CAS Number: 631-01-6. Synonyms: Quillaja Sapogenin. Molecular Formula: C30H46O5. Formula Weight: 486.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 1 mg/ml. SMILES: OC([C@]12[C@](CC(C)(CC2)C)([H])C3=CC[C@@]([C@@]4([C@@]([C@@](C)([C@H](CC4)O)C=O)([H])CC5)C)([H])[C@]5(C)[C@@]3(C[C@H]1O)C)=O. InChi Code: InChI=1S/C30H46O5/c1-25(2)13-14-30(24(34)35)19(15-25)18-7-8-21-26(3)11-10-22(32)27(4,17-31)20(26)9-12-28(21,5)29(18,6)16-23(30)33/h7,17,19-23,32-33H,8-16H2,1-6H3,(H,34,35)/t19-,20+,21+,22-,23+,26-,27-,28+,29+,30+/m0/s1. InChi Key: MQUFAARYGOUYEV-UAWZMHPWSA-N. Origin: Plant/Quillaja saponaria bark.