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![Questiomycin A](https://www.biomol.com/media/image/49/f4/a9/Cay27623-1_600x600.png)
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Questiomycin A is a phenoxazine and a chromophore that has been found in Streptomyces and has... more
Product information "Questiomycin A"
Questiomycin A is a phenoxazine and a chromophore that has been found in Streptomyces and has antibacterial and anticancer activities. It is active against M. scrofulaceum, M. marinum, and M. intracellulare (MICs = 2.8, 11.3, and 5.6 µg/ml, respectively) but not M. tuberculosis, M. smegmatis, M. kansasii, or M. fortuitum (MICs = >45 µg/ml). It is also inactive against E. coli, P. aeruginosa, S. tymphimurium, S. aureus, or L. monocytogenes. It is cytotoxic to a variety of cancer cells, including MCF-7, A549, MIA PaCa-2, and LoVo-1 cells (IC50s = 1.67, 5.48, 7.16, and 20.03 µM, respectively) as well as human umbilical vein endothelial cells (HUVECs) but not human embryonic lung fibroblast cells (HELs, IC50s = 16.06 and >50 µM, respectively). Questiomycin A reduces the increased intracellular pH in a variety of cancer cell lines, as well as in HUVECs and HELs. It prevents lung metastasis in a B16 mouse melanoma model of metastasis when administered at a dose of 0.5 mg/kg simultaneously with B16 cells or every three days. It is also a chromophore product of the reducing agent 2-aminophenol oxidation (as 2-amino-phenoxazine-3-one) and has been used as a readout in the study of catalytic oxidation of 2-aminophenol by various metal-containing complexes. It has an absorbance of 435 nm in methanol.Formal Name: 2-amino-3H-phenoxazin-3-one. CAS Number: 1916-59-2. Molecular Formula: C12H8N2O2. Formula Weight: 212.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2mg/mL, DMSO: 3mg/mL, DMSO:PBS (pH 7.2) (1:20): 0.04mg/mL. lambdamax: 239, 433 nm. SMILES: NC1=CC2=NC3=CC=CC=C3OC2=CC1=O. InChi Code: InChI=1S/C12H8N2O2/c13-7-5-9-12(6-10(7)15)16-11-4-2-1-3-8(11)14-9/h1-6H,13H2. InChi Key: RDJXPXHQENRCNG-UHFFFAOYSA-N. Origin: Synthetic.
Keywords: | 2-amino-3H-phenoxazin-3-one |
Supplier: | Cayman Chemical |
Supplier-Nr: | 27623 |
Properties
Application: | Antibacterial, anticancer phenoxazine |
MW: | 212.2 D |
Formula: | C12H8N2O2 |
Purity: | >98% |
Format: | Solid |
Database Information
CAS : | 1916-59-2| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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