Pyrrolidinedithiocarbamic Acid (ammonium salt)

Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-kappaB activation in vitro (100 µM). At 300 µM, it prevents TNF-alpha gene expression and protein production in human monocytes after LPS application. In vascular smooth muscle cells, PDTC (10 µM) arrests the cell cycle at the G1 phase with upregulation of p21Cip1 through the p38 MAPK pathway. PDTC (100 µM) also has antioxidant properties.Formal Name: 1-pyrrolidinecarbodithioic acid, monoammonium salt. CAS Number: 5108-96-3. Synonyms: PDTC, Pyrrolidinedithiocarbamate. Molecular Formula: C5H8NS2 . NH4. Formula Weight: 164.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/mL, DMSO: 15 mg/mL, DMSO:PBS (pH 7.2) (1:7): 0.12 mg/mL, Ethanol: 0.14 mg/mL. lambdamax: 282, 284 nm. SMILES: S=C([S-])N1CCCC1.[NH4+]. InChi Code: InChI=1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6,/h1-4H2,(H,7,8),1H3. InChi Key: MDDIUTVUBYEEEM-UHFFFAOYSA-N.