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Product information "Pyridostatin (trifluoroacetate salt)"
Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage and cell cycle arrest (Kd = 490 nM) and has been shown to target the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.Formal Name: 4-(2-aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide, trifluoroacetate salt. CAS Number: 1472611-44-1. Molecular Formula: C31H32N8O5 . C2HF3O2. Formula Weight: 710.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 20 mg/mL, Ethanol: 5 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 228, 269, 311, 324 nm. SMILES: NCCOC1=CC(NC(C2=NC(C(NC3=CC(OCCN)=C(C=CC=C4)C4=N3)=O)=CC(OCCN)=C2)=O)=NC5=C1C=CC=C5.C#C(F)(F)F.O=O. InChi Code: InChI=1S/C31H32N8O5.C2HF3.O2/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29,1-2(3,4)5,1-2/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41),1H,. InChi Key: AOHXRDMGALEMBB-UHFFFAOYSA-N.
Keywords:
4-(2-aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide, trifluoroacetate salt
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