Purmorphamine

Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM. Investigation into purmorphamine's mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.Formal Name: 9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine. CAS Number: 483367-10-8. Molecular Formula: C31H32N6O2. Formula Weight: 520.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH7.2) (1:2): 0.25 mg/ml, DMSO: 10 mg/ml. lambdamax: 221, 316 nm. SMILES: O1CCN(CC1)c1ccc(cc1)Nc1nc(Oc2cccc3ccccc23)nc2c1ncn2C1CCCCC1. InChi Code: InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35). InChi Key: FYBHCRQFSFYWPY-UHFFFAOYSA-N.