Prunetin

Description: 1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. 3. Prunetin and biochanin A are potent reducers of NF-kappaB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. 4. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells, Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells, Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells. Target: ERK, Dehydrogenase, NF-kappaB. Smiles: COc1cc(O)c2c(c1)occ(-c1ccc(O)cc1)c2=O. References: Yang G , Ham I , Choi H Y . Anti-inflammatory effect of prunetin via the suppression of NF-kappaB pathway[J]. Food & Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association, 2013, 58:124-132.