Prothionamide

Prothionamide is a bactericidal thioamide effective against M. tuberculosis (MIC = ~0.5 µg/ml), M. leprae (MIC = 0.8-1.6 mg/L), and M. avium. It forms a covalent adduct with nicotinamide adenine dinucleotide that inhibits mycobacterial InhA, the enoyl-acyl ACP reductase involved in mycolic acid biosynthesis, with a Ki value of 2 nM.Formal Name: 2-propyl-4-pyridinecarbothioamide. CAS Number: 14222-60-7. Synonyms: Tebeform. Molecular Formula: C9H12N2S. Formula Weight: 180.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 289, 350 nm. SMILES: NC(C1=CC=NC(CCC)=C1)=S. InChi Code: InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12). InChi Key: VRDIULHPQTYCLN-UHFFFAOYSA-N.