Propafenone-d5 (hydrochloride)

Propafenone-d5 is intended for use as an internal standard for the quantification of propafenone (Cay-21871) by GC- or LC-MS. Propafenone is a class I antiarrhythmic agent. It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively). Propafenone also blocks sodium (INa), potassium (IK), and transient outward potassium currents in various cardiac cells. In vivo, propafenone (2 and 3 mg/kg, i.v.) reverses sinus rhythm in a dog model of barium chloride-induced ventricular arrhythmia. Formulations containing propafenone have been used in the treatment of cardiac arrhythmias.Formal Name: 1-(2-(2-hydroxy-3-(propylamino)propoxy-1,1,2,3,3-d5)phenyl)-3-phenylpropan-1-one, monohydrochloride. CAS Number: 1346605-05-7. Molecular Formula: C21H22D5NO3 . HCl. Formula Weight: 382.9. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: CCCNC([2H])([2H])C(O)([2H])C([2H])([2H])OC1=C(C=CC=C1)C(CCC2=CC=CC=C2)=O.Cl. InChi Code: InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17,/h3-11,18,22-23H,2,12-16H2,1H3,1H/i15D2,16D2,18D,. InChi Key: XWIHRGFIPXWGEF-FIFLIBHCSA-N.