Procyanidin C1

Procyanidin C1 is a polyphenol flavonoid trimer of (-)-epicatechin (Cay-11807) that has HIV-related and antioxidant activities. It activates latent HIV-1 provirus in JLR2 cells when used at concentrations ranging from 12.5 to 50 µM and increases NF-kappaB-dependent transcriptional activity in Jurkat T cells. Procyanidin C1 also scavenges 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 3.2 µg/ml) and inhibits the activity of alpha-glucosidase (IC50 = 3.8 µg/ml) and 15-lipoxygenase (15-LO, IC50 = 57.6 µg/ml). Procyanidin C1 (10 µg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.Formal Name: (2R,2'R,2''R,3R,3'R,3''R,4R,4'S)-2,2',2''-tris(3,4-dihydroxyphenyl)-3,3',3'',4,4',4''-hexahydro-[4,8':4',8''-ter-2H-1-benzopyran]-3,3',3'',5,5',5'',7,7',7''-nonol. CAS Number: 37064-30-5. Synonyms: Proanthocyanidin C1, Procyanidol C1. Molecular Formula: C45H38O18. Formula Weight: 866.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 282 nm. SMILES: OC1=CC=C([C@H]2OC(C([C@H]3C4=C(O)C=C(O)C=C4O[C@H](C5=CC(O)=C(O)C=C5)[C@@H]3O)=C(O)C=C6O)=C6[C@H](C7=C(O)C=C(O)C8=C7O[C@H](C9=CC=C(O)C(O)=C9)[C@H](O)C8)[C@H]2O)C=C1O. InChi Code: InChI=1S/C45H38O18/c46-18-10-27(54)33-32(11-18)61-42(16-2-5-21(48)25(52)8-16)39(59)37(33)35-29(56)14-30(57)36-38(40(60)43(63-45(35)36)17-3-6-22(49)26(53)9-17)34-28(55)13-23(50)19-12-31(58)41(62-44(19)34)15-1-4-20(47)24(51)7-15/h1-11,13-14,31,37-43,46-60H,12H2/t31-,37-,38+,39-,40-,41-,42-,43-/m1/s1. InChi Key: MOJZMWJRUKIQGL-XILRTYJMSA-N. Origin: Plant/Crataegi fructus.