Procyanidin B4

Procyanidin B4 is a polyphenol flavonoid dimer of (+)-catechin (Cay-70940) and (-)-epicatechin (Cay-11807) that has been found in Q. gilva and has diverse biological activities. It scavenges DPPH (Cay-14805) and superoxide radicals (IC50s = 12.15 and 8.67 µM, respectively). Procyanidin B4 inhibits nitric oxide (NO) production in RAW 264.7 macrophages (IC50 = 1.44 µM). It also inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in Raji cells.Formal Name: (2R,2'R,3S,3'R,4S)-2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-[4,8'-bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol. CAS Number: 29106-51-2. Synonyms: (+)-Catechin-(4alpha->8)-(-)-epicatechin, Proanthocyanidin B4, Procyanidol B4. Molecular Formula: C30H26O12. Formula Weight: 578.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetone: soluble, Chloroform: soluble, Dichloromethane: soluble, DMSO: soluble, Ethyl Acetate: soluble. SMILES: O[C@H]1[C@@](C2=C3C(C[C@H]([C@](C4=CC(O)=C(C=C4)O)([H])O3)O)=C(C=C2O)O)([H])C5=C(O)C=C(O)C=C5O[C@]1([H])C6=CC(O)=C(C=C6)O. InChi Code: InChI=1S/C30H26O12/c31-13-7-20(37)24-23(8-13)41-29(12-2-4-16(33)19(36)6-12)27(40)26(24)25-21(38)10-17(34)14-9-22(39)28(42-30(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,22,26-29,31-40H,9H2/t22-,26+,27+,28-,29-/m1/s1. InChi Key: XFZJEEAOWLFHDH-VUGKQVTMSA-N. Origin: Plant/Grape seeds.