Procyanidin B2

Procyanidin B2, one of the most representative naturally occurring edible pigments, is usually isolated from the seeds, fruits and leaves of lots of common plants, such as grapes or apples. Procyanidin B2 has numerous bioactivities, including anti-inflammatory, anti-oxidative stress, neuroprotective, lipid metabolism regulating, wound healing, anti-diabetic, metabolic syndrome regulating, anti-atherosclerotic, anti-adipogenesis, anti-viral and anti-cancer properties. Procyanidin B2 targets and mediates several signaling pathways like NF-kappaB, MAPK, PI3K/Akt, NLRP3, apoptotic axis, VEGF/VEGFR2, PPARgamma and Nrf-2/HO-1. Procyanidin B2 possesses the potential to treat/prevent a wide range of human diseases, such as diabetes mellitus, diabetic complications, atherosclerosis, cancers and non-alcoholic fatty liver disease.