PRLX-93936

Description: PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 µM in a cell-based reporter assay). PRLX-93936 (1 µM) also inhibits hypoxia-induced increases in HIF-1alpha expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM. PRLX-93936 inhibits tumor growth in PANC-1 and HT-1080 xenograft models when administered at a dose of 50 mg/kg and induces tumor regression when administered at a dose of 100 mg/kg. Target: Others. Smiles: C(C=1N(C(=O)C=2C(N1)=CC=CC2)C3=C(OCC)C=CC=C3)N4CCNCC4