Pridopidine

Pridopidine is a ligand of sigma non-opioid intracellular receptor 1 (sigma1 receptor) and a dopaminergic stabilizer. It binds to the sigma1 receptor and dopamine D2 receptor in the high-affinity state (Kis = 81.3 and 7,521 nM, respectively). Pridopidine (100 µmol/kg) increases striatal 3,4-dihydroxyphenylacetic acid (DOPAC) levels and locomotor activity, as well as inhibits amphetamine-induced locomotor activity, in rats. It improves motor function and reduces striatal mutant huntingtin (mHtt) aggregates in the R6/2 mouse model of Huntington's disease when administered at doses of 5 or 6 mg/kg. Pridopidine (30 mg/kg) prevents muscle atrophy and the loss of innervated neuromuscular junctions in the SOD1-G93A mouse model of amyotrophic lateral sclerosis (ALS).Formal Name: 4-[3-(methylsulfonyl)phenyl]-1-propyl-piperidine. CAS Number: 346688-38-8. Synonyms: ACR16, ASP2314, FR310826. Molecular Formula: C15H23NO2S. Formula Weight: 281.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Soluble, Methanol: Soluble. SMILES: O=S(C1=CC(C2CCN(CC2)CCC)=CC=C1)(C)=O. InChi Code: InChI=1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3. InChi Key: YGKUEOZJFIXDGI-UHFFFAOYSA-N.