Praziquantel

Praziquantel is an anthelmintic agent. It is lethal to S. mansoni schistosomula and adults (LC50s = 0.68 and 0.03 mg/ml, respectively). Praziquantel (172 and 592 mg/kg) reduces worm burden in a mouse model of S. mansoni infection. Formulations containing praziquantel have been used in the treatment of schistosomiasis.Formal Name: 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one. CAS Number: 55268-74-1. Synonyms: Embay 8440, (±)-Praziquantel. Molecular Formula: C19H24N2O2. Formula Weight: 312.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 10 mg/ml. SMILES: O=C(N1CC(C(C=CC=C2)=C2CC3)N3C(C1)=O)C4CCCCC4. InChi Code: InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2. InChi Key: FSVJFNAIGNNGKK-UHFFFAOYSA-N.