PPQ-102

The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). PPQ-102 is a cell-permeable pyrimido-pyrrolo-quinoxalinedione that reversibly inhibits CFTR chloride channels with an IC50 value of 90 nM. At 0.5-5 µM, PPQ-102 has been used to reduce the size and number of renal cysts in a neonatal kidney organ culture model of polycystic kidney disease. At 1 µM, PPQ-102 can increase vascular endothelial growth factor-A production in cultured airway epithelial NCI-H292 cells, triggering epidermal growth factor receptor phosphorylation.Formal Name: 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione. CAS Number: 931706-15-9. Synonyms: CFTR Inhibitor IV, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV. Molecular Formula: C26H22N4O3. Formula Weight: 438.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.2 mg/ml. lambdamax: 211, 329 nm. SMILES: CC1=CC=C(O1)C2C3=C4C(C(N(C)C(N4C)=O)=O)=C(C5=CC=CC=C5)N3C6=C(C=CC=C6)N2. InChi Code: InChI=1S/C26H22N4O3/c1-15-13-14-19(33-15)21-24-23-20(25(31)29(3)26(32)28(23)2)22(16-9-5-4-6-10-16)30(24)18-12-8-7-11-17(18)27-21/h4-14,21,27H,1-3H3. InChi Key: MNOOVRNGPIWJDI-UHFFFAOYSA-N.