Pomalidomide 4'-PEG3-azide

Description: Pomalidomide 4'-PEG3-azide is a chemically synthesized E3 ligase ligand-linker conjugate that incorporates the cereblon ligand derived from Pomalidomide, along with a linker. This compound is utilized in the synthesis of iRucaparib-TP3 (Compound 3), an effective PARP1 degrader developed through the PROTAC strategy and derived from Rucaparib. Target: E3 Ligase Ligand-Linker Conjugate, Others. Smiles: [N-]=[N+]=NCCOCCOCCO CCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3. References: Shuai Wang, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec,15(12):1223-1231.