PNU 120596

PNU 120596 is a positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor (nAChR), increasing agonist-evoked calcium flux (EC50 = 216 nM). It has no detectable effect on alpha4beta2, alpha3beta4, or alpha9beta10 nAChRs. PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents in rat hippocampal slices and improves the auditory gating deficit caused by amphetamine in rats. It also reduces the cortical/subcortical infarct volume caused by transient focal cerebral ischemia in rats.Formal Name: N-(5-chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea. CAS Number: 501925-31-1. Synonyms: NSC 216666. Molecular Formula: C13H14ClN3O4. Formula Weight: 311.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL, DMSO: 20 mg/mL. lambdamax: 210, 254, 298 nm. SMILES: ClC1=C(OC)C=C(OC)C(NC(NC2=NOC(C)=C2)=O)=C1. InChi Code: InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18). InChi Key: CEIIEALEIHQDBX-UHFFFAOYSA-N.