PKUMDL-LC-101-D04

Item number	Size	Manual	Delivery time	Price
TGM-T36935-1mg	1 mg	-	7 - 10 business days*	78.00€
TGM-T36935-5mg	5 mg	-	7 - 10 business days*	282.00€
TGM-T36935-10mg	10 mg	-	7 - 10 business days*	419.00€
TGM-T36935-25mg	25 mg	-	7 - 10 business days*	672.00€
TGM-T36935-50mg	50 mg	-	7 - 10 business days*	950.00€
TGM-T36935-100mg	100 mg	-	7 - 10 business days*	1,255.00€
TGM-T36935-500mg	500 mg	-	7 - 10 business days*	2,571.00€

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Description: PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4... more

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Product information "PKUMDL-LC-101-D04"

Description: PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 µM in a cell-free assay, and at a concentration of 61 µM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 µM) reduced cholesterol peroxide-induced MEF death. Target: GPX. Smiles: Cl.NCCNS(=O)(=O)c1ccc(NC(=S)NC2CCCC2)cc1. References: Li C, et al. Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4. J Med Chem. 2019,62(1):266-275.

Keywords:	GPX4-Activator-1d4, PKUMDL-LC-101-D04
Supplier:	TargetMol
Supplier-Nr:	T36935

Properties

Application:	GPX4 allosteric activator
MW:	378.94 D
Formula:	C14H23ClN4O2S2

Database Information

CAS :	2143896-83-5\| Matching products
KEGG ID :	K05361 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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